CD40 Agonist Monoclonal Antibody-Mediated Hepatitis in TNF-Receptor 1 Gene Knockout Mice
نویسندگان
چکیده
Tumor necrosis factor-alpha (TNF-α) plays an important role in liver inflammation. CD40-CD40 ligand (CD40-CD40L) is a key receptor–ligand signaling pair involved the adaptive immune response and pathogenesis of autoimmune diseases. In mice, CD40 activation leads to sickness behavior syndrome (SBS) comprising weight loss, sleep disruption depression, which can be blocked by administration TNF-inhibitor etanercept. present study, we assessed extent hepatic inflammation mice devoid TNF-receptor 1 (TNFR1)-mediated pathway. The TNFR1-depleted (TNFR1−/−) adult their wild type littermates were given single intra-peritoneal injection agonist monoclonal antibody (mAb) or rat IgG2a isotope control. As described previously, TNFR1−/− protected from SBS upon mAb treatment. Cd40, tnf tnfr1 mRNA Tnf-α peptide increased mAb-stimulated mice. Serum alanine aminotransferase was elevated both CD40-activated showed much less intra-parenchymal infiltrates, hepatocellular necrosis, perivascular clusters than littermates. A gene expression microarray detected activity metabolic detoxification pathways decreased inflammatory pathways. We conclude that development CD40L interactions depend on TNFR1-mediated are counteracted alterations
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ژورنال
عنوان ژورنال: Biomedicines
سال: 2021
ISSN: ['2227-9059']
DOI: https://doi.org/10.3390/biomedicines9080863